Not Looking Good!

My endometrium after 48h of G-CSF infusion remains the same at 6.5 mm. It looks trilaminar. I was very disappointed and I am a bundle of negative emotions yesterday. Now I feel it is OK. I beleive everything happens for a reason and hopefully for the good. I will have the next ultrasound on tuesday. Dr.Anjali increased my estrogen dosage from 16 mg to 40 mg. So hopefully we see some improvement by tuesday. If not, I have to decide whether to cancel the cycle, wait for some more time or to go ahead and transfer. My intuition says do an embryo transfer whatever it is! There are studies which did not find any difference in pregnancy rates between thin and thick endometrium. There are studies which talk about the importance of thick endometrium. It will be a a hard decission to take but my heart will break if I have to return with an empty uterus. I do believe that if my embryos are competent enough they will be ok with a thin bedding too ;) Here is the blog post of Dr.Liccardi regarding thin and thick endometrium http://infertilityblog.blogspot.in/2008/08/endometrium-part-iii.html

Update on endometrial ultrasound and G-CSF

I had a vaginal ultrasound yesterday to check for my uterus lining. Not so good news again! After 2 days of 16 mg estrogen (8 progynova tabs) my lining has grown from 6 mm to 6.7 mm. Dr. Malpani suggested that I should have neukine infused into my uterus. Neukine or Filgrastim is nothing but Recombinant Human Granulocyte Colony Stimulating Factor. It is sold under the brand name Neupogen in USA. It is a drug or a cytokine actually sold to prevent decrease in neutrophil count during chemotherapy which causes myelosupression. Decrease in neutrophil counts is called neutropenia and it is accompanied by fever. It causes the patient more prone to infections. Recombinant G-CSF causes a dose-dependent increase in circulating neutrophil counts thus preventing spurious infections in patients receiving myelosuppressive chemotherapy. What does G-CSF has to do with endometrial growth? Please visit this Center For Human Reproduction link for further information. Here is the blog post of Dr.Malpani regarding thin endometrium and the use of G-CSF to improve it.

So today I received an infusion of Neukine inside my uterus. Keeping my legs in that evil stirrup is uncomfortable. Dr.Malpani eased my tension by chatting with me. Still no signs of high estrogen in my body but I wish my endometrium responds well to Neukine giving me a nice, plump lining where my embies can snuggle in and start establishing contacts with me. Mumbai is great, I am very happy today. I will update about my Mumbai adventures soon.
Somemore interesting reads on G-CSF:
http://badplumbing.kurvy.com/2010/12/g-csf-the-last-frontier.html
http://clinicaltrials.gov/ct2/show/NCT01202656