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Showing posts with label endometrial thickness. Show all posts
Showing posts with label endometrial thickness. Show all posts

Saturday, June 22, 2013

A quick update ! When going gets tough ...

I will be having a FET on June 29th, exactly one year after my previous FET. Until previous December, we didn't have holidays; and my attempts to grow my endometrial lining to decent thickness from the beginning of this year failed miserably. My lining would halt at 6.5 mm everytime ! I didn't try anythingelse other than progynova (different doses !). Went in for a hysteroscopy, a month ago, during a dummy FET cycle. Uterus is fine - no problems were detected ! My endometrial lining expressed estrogen and progesterone receptors as it should. There was no infection or malignancy ! During the dummy cycle, exactly one week after my hysteroscopy, my lining was only 4mm. I started progesterone and within 4 days it grew to 8mm. I didn't know lining grows after progesterone support ! Might be I am very unusual in all ways :) ! The speculation is, it is not the actual proliferation of endometrium but just an increase in thickenss of individual cells (change from proliferative to secretory endometrium) after progesterone support. But can it thicken 4 mm ! The happenings are very confusing, and there are no reasonable answers. This cycle I decided not to take more than 4 tabs of progynova (estrogen tablets), whatever may come ! My lining seems to be around 7mm ! Not the best. But we have decided to go for ET. This is the story from my side. I don't know when I will update my blog again. I have promised my DH that I will not sit in front of computer (he feels that I am stressed out because of writing !). I will definitely miss my blog, but I should respect my DH's view too, afterall he goes through a lot of struggle because of me. I will miss writing - it gives me so much solace ! When I start writing again, I would like to make a post about endometrium ! I learned a lot ofcourse ! Please do wish me good luck ! Thank you for all your love and support !

Thursday, June 14, 2012

Update on endometrial ultrasound and G-CSF


I had a vaginal ultrasound yesterday to check for my uterus lining. Not so good news again! After 2 days of 16 mg estrogen (8 progynova tabs) my lining has grown from 6 mm to 6.7 mm. Dr. Malpani suggested that I should have neukine infused into my uterus. Neukine or Filgrastim is nothing but Recombinant Human Granulocyte Colony Stimulating Factor. It is sold under the brand name Neupogen in USA. It is a drug or a cytokine actually sold to prevent decrease in neutrophil count during chemotherapy which causes myelosupression. Decrease in neutrophil counts is called neutropenia and it is accompanied by fever. It causes the patient more prone to infections. Recombinant G-CSF causes a dose-dependent increase in circulating neutrophil counts thus preventing spurious infections in patients receiving myelosuppressive chemotherapy. What does G-CSF has to do with endometrial growth? Please visit this Center For Human Reproduction link for further information. Here is the blog post of Dr.Malpani regarding thin endometrium and the use of G-CSF to improve it.

So today I received an infusion of Neukine inside my uterus. Keeping my legs in that evil stirrup is uncomfortable. Dr.Malpani eased my tension by chatting with me. Still no signs of high estrogen in my body but I wish my endometrium responds well to Neukine giving me a nice, plump lining where my embies can snuggle in and start establishing contacts with me. Mumbai is great, I am very happy today. I will update about my Mumbai adventures soon.
Somemore interesting reads on G-CSF:
http://badplumbing.kurvy.com/2010/12/g-csf-the-last-frontier.html
http://clinicaltrials.gov/ct2/show/NCT01202656
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