tag:blogger.com,1999:blog-4970758006706422699.post7419316422639699673..comments2024-02-14T13:29:46.876+01:00Comments on A Pursuit to Perpetuate My Genes: Comprehensive Chromosome Screening - panacea or pipe dream? - Part-1Manjuhttp://www.blogger.com/profile/09465166865789437941noreply@blogger.comBlogger4125tag:blogger.com,1999:blog-4970758006706422699.post-44892107284734238212012-10-10T10:31:43.410+02:002012-10-10T10:31:43.410+02:00Thanks Jay!
It is surprising to know that a woman...Thanks Jay!<br /><br />It is surprising to know that a woman of 32 can have two miscarriages due to aneuploidy!(ofcourse the third might have been due to anueploidy too!) <br /><br />I too agree that blastocyst biopsy is better and the issue of mosaicism is of minor concern. <br /><br />Hope PGD gives you the answers you need!Manjuhttps://www.blogger.com/profile/09465166865789437941noreply@blogger.comtag:blogger.com,1999:blog-4970758006706422699.post-90554685198206352092012-10-09T10:51:05.361+02:002012-10-09T10:51:05.361+02:00I had turned 30 when I had my first loss, which wa...I had turned 30 when I had my first loss, which was chromosomally normal, but hey, they got to read 3 hardy cells of the placenta about an easy 3 weeks after embryonic death. A few months after that, I had my second loss, which was chromosomally abnormal.I had just turned 32 when I conceived my 3rd pregnancy, which was also chromosomally abnormal. <br /><br />And yes, I'm using the same donor again. The only way he could be contributing if there is some genetic incompatibility between us (such as each of us having one copy of an embryonic lethal recessive mutation or something), but that is a super low odds probability.The higher odds are that the issue is with me. <br /><br />I think the thing that swung me for PGD was my own experience and also the finding that even with a women using egg donors(such as Brave IVF GIRL) almost 30-40 % of embryos were aneuploid. There are many, many studies that support that is is probably the basal level of aneuploidy in IVF-generated embryos. The question is whether women with infertility have an even higher level of aneuploidy-- if so one saves a lot of time and heartache and money by eliminating the ones that have no chance of succeeding. However, there remains the flip side, the practical difficulties of performing PGD, and the issue of mosaicism. From what I've read I'd agree with Dr. Malpanis conclusions- a blastomere biopsy is no good, the risk-benefit ratio skews heavily in favor of risk.<br />A tropectoderm biopsy, done by capable hands with a good testing platform, skews in favor of benefit, IMO. So at the end of the day, it comes down to practicalities of whether one has the resources to actually test, with minimal damage to the embryos.<br /><br />I liked your point about aneuploidy being likely confined to cells that form the placenta in the blastocyst and the resulting mislabeling of the embryoas aneuploid. Its a relevant point, but this, IMO represents an acceptable risk, if you have a lot of embryos to test. If you have a very small number of embryos, then of course your best chance is to leave it to mother nature.<br /><br />Please feel free to ask questions or comment if you see any debatable point on my blog! I'd welcome it, and it would liven things up :) Anonymoushttps://www.blogger.com/profile/15553205805046479504noreply@blogger.comtag:blogger.com,1999:blog-4970758006706422699.post-68597560256435524772012-10-08T07:59:32.000+02:002012-10-08T07:59:32.000+02:00Dear Jay,
Thamks : ) I got the interest to read a...Dear Jay,<br /><br />Thamks : ) I got the interest to read about CCS after I saw your post. Then thought why not make a short write-up and it ended up very long : )<br /><br />Jay, if I can ask you-how old are you? Are you using the same donor again? I am not sure whether all women with RPL should do CCS especially when no detectable chromosomal abnormality is present in their conceptus.<br /><br />You know about me-right? A bit conservative biologist! To tell the truth I am tempted when I first read the very positive CCRM papers-69% implantation rate (with heart tone!), great! But my further read about their publications did not convince me. It is hard to think that it can be a panacea for women like us. I have 5 frozen embies. I will transfer them and see where my journey leads me to. If I get a chance I would love to experiment too but I am wondering whether I could afford such a costly experiment and the emotional turmoil will be high too!<br /><br />But I am eagerly watching your journey Jay. Lots of good luck! I want to ask you many things but then felt I should not be too inquisitive and so kept quiet.<br /><br />I am actually very happy to see your comment. Read my other posts on this topic. I would love to have a serious arguement-perhaps it benefits us both! I will be delighted to argue with an intelligent person like you. Correct me too if I am wrong somewhere.<br /><br />Love<br />ManjuManjuhttps://www.blogger.com/profile/09465166865789437941noreply@blogger.comtag:blogger.com,1999:blog-4970758006706422699.post-57038224198044419992012-10-07T20:34:21.133+02:002012-10-07T20:34:21.133+02:00Very nice and comprehensive post. I'd just add...Very nice and comprehensive post. I'd just add that I've had RPL, with 3 losses, and I know for a fact that 2 out of my 3 losses have been due to aneuplodies. But then, I'm neither of advanced maternal age and both my donor and I have normal karyotypes. <br /><br />What I'm trying to say is, anybody with RPL should also qualify, even if they have never tested the products of conception for aneuplodies.<br /><br />Are you planning on jumping back in the saddle soon?<br /><br />Anonymoushttps://www.blogger.com/profile/15553205805046479504noreply@blogger.com